Advances on Glutathione S-transferases of insects
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Key Words:glutathione S-transferases, insecticide, genomic, resistance
Abstract:Glutathione S-transferases (GSTs) include members of a large family of multifunctional intracellular enzymes involved in the detoxification of endogenous and xenobiotic compounds that can be found ubiquitously in aerobic organisms. GSTs are taken to be important components involved in the process of developing resistance to the insecticides of organophosphorus, pyrethroids and organochlorines. They can be generally classified into six major categories, among which Delta and Epsilon are insect-specific. Most resistance-related genes are identified from these two categories. The number of GSTs has been increasing with the rapid development of insect genome sequencing, which have greatly facilitated the research on their biologically interacting functions. Further studies on the GST genes will ultimately improve our understanding on the molecular insights of insect resistance to insecticides