The oriental fruit moth, Grapholita molesta (Busck), is a major pest of fruit crops worldwide that causes serious damage in most fruit-growing areas. Control of this pest has mainly depended on chemical pesticides which have undesirable side effects, for example, reducing the abundance of natural predators of pests and environmental pollution from pesticide residues. In contrast, using predators to control the oriental fruit moth is both effective, and produces no pesticide residues or other environmental pollution. This paper reviews previous research on biological control agents for the OFM, including pathogenic microorganisms, parasites, predators, sex pheromones, and semiochemicals. Potential future developments in the biological control of this pest are also discussed.