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Issue:ISSN 2095-1353
           CN 11-6020/Q
Director:Chinese Academy of Sciences
Sponsored by:Chinese Society of Entomological;institute of zoology, chinese academy of sciences;
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Your Position :Home->Past Journals Catalog->2021年58 No.2

Advances in research on serine protease inhibitors (Serpins) and their role in regulating insect immune systems
Author of the article:ZHOU Shi-Min;GU Qi-Juan;HUANG Jian-Hua;SHI Min;CHEN Xue-Xin
Author's Workplace:Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China
Key Words:insect immunity; Serpins; Toll signaling pathway; PPO activation cascade; entomopathogens
Serine protease inhibitors (Serpins) are involved in the regulation of various physiological processes common in all living organisms. In this review, we summarize recent published papers on insect serpins involved in the Toll signaling pathway, which produce antimicrobial peptides and regulate the prophenoloxidase (PPO) activation cascade which induces melanogenesis in model insects such as Drosophila melanoganster, Tenebrio molitor and Manduca sexta. In addition, we review research on serpins from entomopathogens, including viruses, nematodes, bacteria, fungi and parasitoids involved in the immuno-regulation of insect hosts.
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