Network analysis of Aspongopus chinensis defense secretions
Author of the article:YU Heng-Mei;ZHAO Shuai;GUO Jian-Jun
Author's Workplace:Institute of Entomology, Guizhou University; Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region; Scientific Observing and Experimental Station of Crop Pest in Guiyang, Ministry of Agriculture and Rural Affairs of the P. R. China, Guiyang 550025, China;Institute of Entomology, Guizhou University; Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region; Scientific Observing and Experimental Station of Crop Pest in Guiyang, Ministry of Agriculture and Rural Affairs of the P. R. China, Guiyang 550025, China;Institute of Entomology, Guizhou University; Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region; Scientific Observing and Experimental Station of Crop Pest in Guiyang, Ministry of Agriculture and Rural Affairs of the P. R. China, Guiyang 550025, China
Key Words:biological defense secretions; Aspongopus chinensis; network pharmacology; bioinformatics; chemical carcinogenesis
Abstract:
[Objectives] Defensive secretions play an important role
in the evolution, growth and reproduction of organisms, and also in their
defense against natural enemies and information transmission. This paper
explores the application of network pharmacology in the study of defensive
secretions, with the goal of providing some new ideas for the study of
biological defense secretions. [Methods]
We analyzed the possible effects of secretions of Aspongopus
chinensis Dallas, based on the known components identified from network
pharmacology and bioinformatics methods. [Results] The components of the defensive secretions of A. chinensis were complex, and the target of 5/12 components was not
predicted by the database. Bioassay targets of secretions are widely
distributed and play important roles in biological processes, such as
metabolism and information transfer, as well as in molecular functions such as
enzyme and receptor functional activities. They may also be closely related to
chemical carcinogenesis, information transfer, germ cell maturation and other
pathways. [Conclusion] The components of A. chinensis defense
secretions are complex, and play functional roles in information transmission
and metabolism.