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Issue:ISSN 2095-1353
           CN 11-6020/Q
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Your Position :Home->Past Journals Catalog->2022年59 No.3

Network analysis of Aspongopus chinensis defense secretions
Author of the article:YU Heng-Mei;ZHAO Shuai;GUO Jian-Jun
Author's Workplace:Institute of Entomology, Guizhou University; Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region; Scientific Observing and Experimental Station of Crop Pest in Guiyang, Ministry of Agriculture and Rural Affairs of the P. R. China, Guiyang 550025, China;Institute of Entomology, Guizhou University; Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region; Scientific Observing and Experimental Station of Crop Pest in Guiyang, Ministry of Agriculture and Rural Affairs of the P. R. China, Guiyang 550025, China;Institute of Entomology, Guizhou University; Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region; Scientific Observing and Experimental Station of Crop Pest in Guiyang, Ministry of Agriculture and Rural Affairs of the P. R. China, Guiyang 550025, China
Key Words:biological defense secretions; Aspongopus chinensis; network pharmacology; bioinformatics; chemical carcinogenesis
Abstract:
[Objectives]  Defensive secretions play an important role in the evolution, growth and reproduction of organisms, and also in their defense against natural enemies and information transmission. This paper explores the application of network pharmacology in the study of defensive secretions, with the goal of providing some new ideas for the study of biological defense secretions. [Methods]  We analyzed the possible effects of secretions of Aspongopus chinensis Dallas, based on the known components identified from network pharmacology and bioinformatics methods. [Results]  The components of the defensive secretions of A. chinensis were complex, and the target of 5/12 components was not predicted by the database. Bioassay targets of secretions are widely distributed and play important roles in biological processes, such as metabolism and information transfer, as well as in molecular functions such as enzyme and receptor functional activities. They may also be closely related to chemical carcinogenesis, information transfer, germ cell maturation and other pathways. [Conclusion]  The components of A. chinensis defense secretions are complex, and play functional roles in information transmission and metabolism.
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