Advances in research of gamma-aminobutyric acid receptors of insects
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Key Words：GABA receptor, subunit, resistance, molecular biology
Abstract：As an inhibitory neurotransmitter distributed widely in the central nervous system of vertebrates and invertebrates, γ-aminobutyric acid (GABA) inhibits nerve transmission, causes hyper-polarization of the postsynaptic membrane and thus inhibits the generation of action potential. The normal synaptic transmission in animals (insects) would be interfered under the condition of the occupation or breakage of GABA receptor, which finally causes the death of organisms. Some pesticides such as cyclopentadienes and avermectins have been developed based on the mechanism. In recent years, the research on GABA receptor gene and its expression has provided convincing data for physiological function of the diverse GABA receptor subunits and their response to pesticides.