Galleria mellonella L. is widely used for insect physiology and biochemistry, insecticide screening, insect toxicology and so on, therefore good and cheap artificial diets are important for mass rearing of G.mellonella. As the main components, milk powder and yeast powder were studied. Five groups of artificial diets were used for rearing G. mellonella. Based on the comparison of different stages and laying eggs, the optimized diet was obtained, with milk powder 50 g, yeast powder 20 g, wheat flour 100 g, wheat bran 100 g, maize flour 100 g, wax 50 g, honey 50 g and glycerine 60 g. It was confirmed that yeast powder had important positive effect on larvae and pupae development and reproductive performance, and milk powder had the positive effect on larvae development and reproductive performance, but the effect was not as strong as yeast powder. Furthermore they had no effect on the longevity of adult moths.