Progresses of insect cytoplasmic polyhedrosis virus
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Key Words:cytoplasmic polyhedrosis virus (CPV), structure, molecular biology, biocontrol
Abstract: Cytoplasmic polyhedrosis viruses (CPVs) belong to the genus Cypovirus in the familiy Reoviridae, and are divided into 19 distinct electrophoretypes on the basis of variation in the electrophoretic migration patterns of genome segments. They are unique within the Reoviridae family in having a single-layer capsid contained within a polyhedrin inclusion body, yet being fully capable of cell entry and endogenous RNA transcription. CPVs can attack 221 insect hosts causing chronic infections. Great progress has been made in sequencing CPV genomes. The genome of two type 1 CPVs from Bombyx mori, type 1 and type 14 from Lymantria dispar and type 15 from Trichoplusia ni, have been fully sequenced and deposited in GenBank. These sequences provide more genetic information for studying the evolutionary relationship and origins of cypoviruses. This paper summarizes recent research on the structure, infection characteristics, genome characteristics of CPVs and their possible future applications.