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2012年49 No.5
Inhibitory effect of cantharidin on PP2A in several kinds of animals
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Key Words： Mylabris cichorii，cantharidin，PP2A，IC50，toxicity
Abstract： We used the colorimetric protein phosphatases inhibition assay to study the inhibitory effect of cantharadin extracted from meloids on PP2A in horses，rabbits，pigs，chickens and Mylabris cichorii (L． )． Cantharidin had an inhibitory effect on horse，pig and rabbitPP2A with IC50 values of0.07 g/L，0.12 g/L and0.23 g/L，respectively． The results suggest that although horses，pigs and rabbits are sensitive to cantharidin，chickens andM． cichoriiare not．