果蝇衰老与昼夜节律和睡眠相关的研究进展
Progress in research on the relationship between aging, circadian rhythm and sleep in Drosophila
吕鹏飞 赵章武 杜 娟
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DOI：10.7679/j.issn.2095-1353.2021.125
作者单位：中国农业大学植物保护学院，农业部作物有害生物监测与绿色防控重点实验室，北京 100193；中国农业大学植物保护学院，农业部作物有害生物监测与绿色防控重点实验室，北京 100193；中国农业大学植物保护学院，农业部作物有害生物监测与绿色防控重点实验室，北京 100193
中文关键词：果蝇；昼夜节律；睡眠；衰老；钟基因
英文关键词：Drosophila; circadian rhythm; sleep; aging; clock genes
中文摘要：
人类和果蝇都具有保守的昼夜节律系统。对果蝇因衰老而引起的节律和睡眠变化的相关研究是了解人类衰老后身体机能发生怎样变化的重要途经。昼夜生物钟节律系统主要包括输入系统、核心时钟系统和输出系统。睡眠是生物周期性出现的一种自发和可逆的静息状态，普遍存在于低等和高等生物中。昼夜节律和睡眠都会随着果蝇的衰老而逐渐变弱。早期研究表明，衰老后昼夜节律系统变弱跟体内外周神经元的钟基因表达量大幅度降低有关，但是衰老后核心钟基因的表达量变化却不清楚。本文对果蝇中节律、睡眠及其与衰老关系的研究进行综述
英文摘要：
Both Drosophila and humans have a conservative circadian system. Research on the effects of
aging on the circadian rhythm and sleep in Drosophila may aid understanding similar effects of aging in humans. The circadian clock
is mainly comprised of an input system, core clock system and output system.
Sleep is a kind of spontaneous, periodic and reversible resting state that is
found in both simple and complex organisms. Circadian rhythm and sleep
gradually weaken with age in Drosophila.
Early in vivo and in vitro studies have found that the weakening of the
circadian rhythm system with age in Drosophila is related to significant reduction in expression of the clock
gene in peripheral neurons. However, the effects of aging on the expression of
core circadian genes remains unclear. This paper reviews recent progress in
research on the effects of aging on circadian rhythm and sleep in Drosophila.