蜱是一类专性吸血的体表寄生节肢动物，能够携带并传播多种病原体和毒素，是畜牧传染疾病防控环节中的重要媒介生物。蜱类相关研究起步较晚，相关基因组、转录组以及蛋白质组的背景信息不清晰，蜱类生理调节特征、蜱媒疾病传播途径和致病机理、传播规律和预防防治策略等方面的研究尚不系统和深入。随着基因组测序技术以及基于质谱的蛋白质组学技术的发展，为利用多种分子生物学技术开展蜱类基因和蛋白质相关研究创造了条件。本文回顾了近十年蛋白质组学技术在蜱类研究中的应用及进展，解读了蜱类相关蛋白质研究的发展历程、研究现状和水平，为开展蜱类的进一步研究、综合防治以及蜱媒疾病的预防和治疗等方面开阔了思路。

Ticks are obligate blood-sucking parasitic arthropods that are important vectors of infectious viruses and other pathogens. Research on ticks began relatively late, and background information on their genomes, transcriptomes, and proteomes remains unclear. Research on the physiological regulation of ticks, the transmission routes of tick-borne pathogens, the pathogenic mechanisms of tick-borne diseases, transmission rules, prevention and control strategies, have not been systematically studied in-depth. With the innovation of genome sequencing and mass spectroscopy-based proteomics, tick gene and protein detection have become faster and easier, allowing the application of a variety of molecular techniques to tick-related studies. This paper reviews progress in the application of proteomics to tick research over the past decade, describes the current status and level of research on tick-related proteins, and presents our thoughts on the comprehensive prevention and control of ticks and the prevention and treatment of tick-borne diseases.