家蚕抗核型多角体病毒病育种研究进展
Progress in the Breeding for Bombyx mori Resistant Variety to BmNPV
叶明强，邝哲师，赵祥杰，吴福泉，李庆荣，肖阳，罗国庆
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作者单位：广东省农业科学院农业生物技术研究所
中文关键词：家蚕，核型多角体病毒，抗性，基因，育种
英文关键词：Bombyx mori, nuclear polyhedrosis virus, resistance, gene, breeding
中文摘要：家蚕核型多角体病毒（Bombyx mori nuclear polyhydrosis virus，BmNPV）病是蚕业界上最常见、危害比较严重的病害；遗传学研究和抗性分析表明，家蚕对核型多角体病毒抗性由主效基因和微效基因协同控制。在蚕病防治方面，除了加强消毒以外，选育抗病毒新品种无疑是更加经济有效的办法。近年来，随着基因组学和新一代测序技术的迅猛发展，覆盖深度达8.5倍家蚕基因组图谱完成和40个家蚕品种和野生种重测序的完成，为家蚕的抗核型多角体病毒病育种提供了理论依据和基因资源。本文综述了BmNPV基因组研究、家蚕基因组研究以及家蚕抗性品种培育方面取得的进展。
英文摘要：Bombyx mori nuclear polyhedrosis virus（BmNPV）is one of most serious disease to B. mori. The resistance of B. mori to BmNPV was genetic controlled by the interaction of major and minor genes. Breeding for resistant variety to BmNPV is the most effective and economical approach. With great advance in genomics and next generation sequencing technologies, the 8.5-fold sequence coverage of genome was assembled and a single-base pair resolution silkworm genetic variation map was constructed from 40 domesticated and wild silkworms which would provide molecular base and gene resources in the control of BmNPV and other traits. This paper reviews the progress of the genomics of BmNPV and silkworms and advance in breeding for resistant variety including traditional, molecular marker-assistant selection and transgenic breeding.