器官成形素调控果蝇翅芽细胞形貌的研究进展

The research progress of morphogenregulated cell morphogenesis during Drosophlia wing disc development

刘素宁，王 丹，沈杰

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作者单位：中国农业大学昆虫学系 北京 100193

中文关键词：器官成形素， 细胞形貌发生， 果蝇， 翅芽

英文关键词：morphogen, cell morphogenesis, Drosophila, wing disc

中文摘要：   果蝇翅芽是研究细胞形貌发生的模式系统。在果蝇翅芽的发育过程中，器官成形素由浓度高的区域（成形素表达细胞）向浓度低的区域（接收细胞）移动，形成动态的浓度梯度。器官成形素信号通路的激活调控翅芽细胞的形貌发生、存活、生长和分化。目前已鉴定的在翅芽细胞表达的器官成形素包括Hedgehog（Hh），Decapentaplegic（Dpp）和Wingless（Wg）。结合国际最新研究进展，本文综述了3种器官成形素在翅芽细胞形貌发生过程中的重要作用，讨论了细胞形貌发生的分子机制。

英文摘要：      Drosophila wing disc is a good model system to study the cell morphogenesis. During the development of the larval wing discs, morphogens secrete from high concentration region to low concentration receiving cells to form a dynamic gradient. Morphogen signaling pathways regulate the cell morphogenesis, survival, proliferation, and differentiation. Up to date, three morphogens have been identified in the wing discs, which are Hedgehog (Hh), Decapentaplegic (Dpp), and Wingless (Wg). In this review, we summarize the functions and discuss the molecular mechanisms of these three morphogens in cell morphogenesis.

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