昆虫神经肽SIFamide及其受体的研究进展
Progress in research on the insect neuropeptide SIFamide and its receptor
令狐俊洪，龚 伟，罗丽林，乙天慈，桂顺华，刘同先
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DOI：10.7679/j.issn.2095-1353.2023.066
作者单位：贵州大学昆虫研究所，贵州省山地农业病虫害重点实验室，贵阳 550025
中文关键词：昆虫神经肽；SIFamide；SIFamide受体；功能研究；研究进展
英文关键词：insect neuropeptides; SIFamide; SIFamide receptor; functional studies; research progress
中文摘要：
昆虫神经肽是昆虫细胞通讯中重要的化学信号，在昆虫的生长发育、代谢、行为等生命过程中起着至关重要的作用。昆虫神经肽SIFamide（SIFa）是由10-15个氨基酸残基组成的短肽，其羧基端为保守的-SIFamide（-amide表示酰胺化）结构。SIFa主要由昆虫脑间部的4个神经元分泌，并通过激活特异性G蛋白偶联受体SIFa receptor（SIFaR）参与调节昆虫求偶、睡眠、摄食等行为。本文概述了SIFa及SIFaR的发现与分布、结构特征及生理功能等方面研究进展，并对以SIFa/SIFaR信号通路为靶标的新型农药创制进行了展望。
英文摘要：
Insect neuropeptides play a vital role in chemical communication between cells, and consequently in growth, metabolism and behavior. The insect neuropeptide SIFamide (SIFa) is a short peptide comprised of 10-15 amino acid residues with a conserved ‘-SIFamide’ motif at the carboxyl terminus. SIFa is mainly secreted from the four pars intercerebralis neurons of brain, and is involved in the regulation of courtship, sleep and feeding behaviors via activation of the specific G protein-coupled receptor (SIFa receptor, SIFaR). Here, we summarize progress in research on the structural characteristics and physiological functions of SIFa and its receptor, and review the prospects of developing specific pesticides targeting the SIFa/SIFaR pathway to control important insect pests.