昆虫谷胱甘肽 S-转移酶的研究进展
Advances on Glutathione S-transferases of insects
尤燕春1,2,3,4 谢苗1,2,3,4 尤民生1,3,4
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作者单位：1.福建农林大学应用生态研究所 福州 350002；2.福建农林大学生命科学学院 福州 350002；3.农业部闽台重点实验室 福州 350002；4. 福州 350002
中文关键词：谷胱甘肽 S-转移酶，杀虫剂，基因组学
英文关键词：glutathione S-transferases, insecticide, genomic, resistance
中文摘要： 谷胱甘肽S-转移酶GSTs是一类广泛分布于生物体的多功能解毒酶系，参与许多内外源有毒物质的代谢。GSTs作为重要的解毒酶，它参与昆虫对有机磷、拟除虫菊酯和有机氯等杀虫剂的抗性形成。昆虫GSTs目前主要分成6个已知家族，其中Delta和Epsion家族是昆虫特异的家族，已鉴定的抗性相关基因则主要分属于这两个家族。随着部分昆虫全基因组测序的完成，越来越多的GSTs得到鉴定，关于GSTs的功能及其作用机制的研究也方兴未艾。进一步研究昆虫GST基因的调控机制，有助于揭示昆虫抗药性形成和发展的分子机理。本文主要对昆虫细胞质GSTs的分类、基因组研究及其在抗药性中的作用等相关研究进展进行综述。
英文摘要：Glutathione S-transferases (GSTs) include members of a large family of multifunctional intracellular enzymes involved in the detoxification of endogenous and xenobiotic compounds that can be found ubiquitously in aerobic organisms. GSTs are taken to be important components involved in the process of developing resistance to the insecticides of organophosphorus, pyrethroids and organochlorines. They can be generally classified into six major categories, among which Delta and Epsilon are insect-specific. Most resistance-related genes are identified from these two categories. The number of GSTs has been increasing with the rapid development of insect genome sequencing, which have greatly facilitated the research on their biologically interacting functions. Further studies on the GST genes will ultimately improve our understanding on the molecular insights of insect resistance to insecticides