细胞色素P450介导抗性的进化可塑性
Evolutionary plasticity of cytochrome P450 mediated insecticide resistance
邱星辉**；李 梅 ； 何凤琴
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作者单位：中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 北京 100101
中文关键词：细胞色素P450， 杀虫剂抗性， 进化可塑性
英文关键词：Cytochrome P450, insecticide resistance, evolutionary plasticity
中文摘要：细胞色素P450是超基因家族，由其介导的杀虫剂代谢解毒的增强是昆虫产生抗药性的普遍而主要的机制。近年的研究表明，细胞色素P450介导的代谢抗性表现出一定程度的进化可塑性：即使是同种昆虫的不同种群在相同种类杀虫剂的胁迫下，进化选择出的抗性相关的细胞色素P450也有所不同，抗性的产生也可以是几种不同细胞色素P450协同作用或控制P450表达的调控因子的不同。
英文摘要：Cytochrome P450 in insects is a supergene family. Increased detoxification of insecticides mediated by cytochrome P450s was proved to be an important and common mechanism of insecticide resistance. Recently, several studies have shown that insecticide resistance appears to evolve using different P450s or/and more than one P450 isoforms, and possibly different regulatory factors controlling P450 expression, even in insect strains selected with the same insecticide, indicating that the cytochrome P450 monooxygenases have some degree of plasticity in response to insecticide pressure: