【目的】 本试验旨在探讨桑叶中添加三聚氰胺（Melamine，MEL）对家蚕的生长和血清生化指标的影响，进而揭示三聚氰胺在家蚕体内的代谢途径和毒理学特征。【方法】 选取大小基本一致、发育整齐的5龄家蚕600头，随机分成4组（每组3个处理重复，每个重复区50头家蚕，雌雄各半）。对照组饲喂新鲜桑叶，试验组添饲3种非致死浓度水平的三聚氰胺（10、15、20 mg/kg），从起蚕起连续饲喂72 h，测定表型和血淋巴生化指标。【结果】 添食三聚氰胺导致家蚕体质量日增长率的相对下降，20 mg/kg剂量的三聚氰胺抑制效果达到显著水平（P<0.05）。家蚕血淋巴糖代谢水平升高，血脂含量降低，而黄嘌呤氧化酶和尿酸含量变化趋势不明显。【结论】 桑叶中添加三聚氰胺显著影响了家蚕的体质量增长，以及体内糖代谢和脂代谢，对尿酸代谢的影响较小。

 [Objectives]  To investigate the effects of adding melamine (MEL) to mulberry leaves on the growth and serum biochemical indices of silkworms, and thereby reveal the metabolic pathways by which ingestion of a nonlethal dose of MEL produces toxic effects in this species. [Methods]  600 newly exuviated 5th instar larvae of approximately the same size were randomly divided into four groups, each group having 3 replicates of 50 silkworms (25 males and 25 females). The control group were fed fresh mulberry leaves whereas the three treatment groups were fed fresh mulberry leaves to which one of three nonlethal doses (10, 15 and 20 mg/kg) of MEL had been added. Monitoring of phenotypic and serum biochemical indices began 5-days after silkworms had begun feeding. [Results]  The addition of MEL slowed the relative growth rate of larvae, significantly so (P<0.05) in the 20 mg/kg MEL treatment group. Glycometabolism and haemolymph levels increased with MEL whereas blood lipid content declined. The addition of MEL had no obvious effect on xanthine oxidase and uric acid content. [Conclusion]  The addition of melamine to mulberry leaves significantly affected the growth, carbohydrate metabolism and lipid metabolism, of silkworm larvae, but appeared to have little effect on their uric acid metabolism.