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CN 11-6020/Q
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2012年49 No.6
Inhibition of glutathione S-transferase activity by insecticidesand allelochemicals in Clostera anastomosis
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Key Words：Clostera anastomosis，glutathione S-transferase，insecticides，plant allelochemicals，inhibition
Abstract： biochemical investigation was made into the inhibition of glutathione S-transferase (GST) activity inClosteraanastomosis ( L． ) by insecticides and allelochemicals． The results showed that different inhibitors have different effects onthe inhibition of GST activity． When the final concentration of insecticides and allelochemicals was 8. 34 × 10 － 5 mol /L，quercetin and tannic acid were the most potent inhibitorstested，with inhibition percentages of GSTs in C． anastomosis of64. 41% and 58. 61% ． Among the inhibitors tested，triazophos，chlorpyrifos，phoxim，hexaflumuron，fipronil andpyridaben were inhibitoryandomethoate，isocarbophos，profenofos，malathion，methomyl，bifenthrin，beta-cypermethrin，
fenpropathrin，lambda-cyhalothrin，imidacloprid and acetamiprid were moderately inhibitory． Other insecticides were lessinhibitory． Furthermore，quercetin，tannic acid and phoxim inhibited GST activity in vitro in a dose-dependent manner．The I50 values of these three inhibitors for GST activity in Canastomosis larvae were 2. 19 × 10 － 7 mol /L，2. 53 × 10 － 7mol /L and 0. 15 × 10 － 7 mol /L，respectively． The results indicate that quercetin and tannic acid have good potential tocontrol C． anastomosis．