Abstract  [Aim]  This study aims to investigate the trend in resistance development in Tuta absoluta (Meyrick) to tetraniliprole, and its cross-resistance to seven other insecticides. This research will provide a theoretical basis for the field application of tetraniliprole. [Methods]  Resistance of T. absoluta to tetraniliprole was tested in the laboratory using the leaf dipping method. Subsequently, the resistance development trend and degree of cross-resistance were analyzed. [Results]  After 11 generations of indoor selection over 14 generations, a strain with a resistance ratio of 18.67 times was obtained. The realized resistance heritability of Tuta absoluta to tetraniliprole was 0.188 5. Tetraniliprole resistance is expected to increase 10-fold in 3.59-8.00 generations under selective pressures of 50%-90%. The resistant strain had obvious cross-resistance to indoxacarb, and the resistance ratio was 8.89. Negative cross-resistance to emamectin benzoate and Bacillus thuringiensis was 0.8 and 0.25-fold, respectively. There was no cross-resistance to chlorantraniliprole, spinosad, chlorpyrifos, or lambda-cyhalothrin, with resistance ratios of 3.58, 2.39, 1.8, and 1.73-fold, respectively. [Conclusion]  There is a risk of T. absoluta developing resistance to teraniliprole. Furthermore, the resistant strain of T. absoluta can produce cross-resistance with several other insecticides. These results establish a theoretical basis for the scientific application of teraniliprole in the field and promote the judicious rotation of pesticide use.