Abstract  [Aim] To investigate possible components and mechanisms of Aspongopus chinensis decoction against hepatocellular carcinoma using network pharmacology. [Methods] After determining the components of A. chinensis decoction, databases (Pubchem and SwissTargetPrediction) were used to collect the top 50 components and their possible targets. The GeneCards, Drugbank, and DisGeNET databases were used to identify possible targets for hepatocellular carcinoma treatment. Cytoscape 3.9.0 was used to construct a drug-component-target-disease and component-target-pathway network, and the STRING and cytoHubba databases were used to build a PPI network. Finally, the Metascap database was used to conduct KEGG and GO enrichment analyses to obtain the key pathways, components and targets for treatment. [Results]  The 15 components (Adenosine, etc.) of A. chinensis decoction may regulate 20 cancer-related pathways through 13 targets (EGFR, MAPK1, CCND1, etc.). This could potentially have a therapeutic effect on hepatocellular carcinoma. [Conclusion]  A. chinensis decoction may cure hepatocellular carcinoma through multiple components, targets, and pathways.