Abstract  [Aim]  To determine the effectiveness of using Orius strigicollis, in combination with Cheilomenes sexmaculata, as biological controls for three important insect potato disease vectors, Frankliniella occidentalis, Myzus persicae and Macrosiphum euphorbiae. [Methods]  The functional response of O. strigicollis and C. sexmaculata was measured, as was the predation rate of each species at different population densities. Finally, the effectiveness of releasing either O. strigicollis, C. sexmaculata, or both species together, was determined in indoor experiments. [Results]  The predatory functional responses of both species to all three insect pests were consistent with the HollingⅡ functional response model. The predation number of O. strigicollis to F. occidentalis, M. persicae and M. euphorbiae was 66.23, 36.90 and 49.26, respectively, whereas that of C. sexmaculata was 312.50, 153.85 and 263.16, respectively. Both O. strigicollis and C. sexmaculata had a greater predatory capacity for nymphal instars of the three pest species than they did for adults of these species. The interference coefficients of O. strigicollis with respect to F. occidentalis, M. persicae and M. euphorbiae were 0.25, 0.11 and 0.19, respectively, whereas those of C. sexmaculata were 0.07, 0.06 and 0.05, respectively. Compared to the control (no natural enemies), releasing either O. strigicollis, C. sexmaculata, or a combination of these species, effectively controlled all three pests after 16 d. [Conclusion]  Releasing both predator species may have been more effective for controlling thrips and aphids. Releasing both O. strigicollis and C. sexmaculata has the potential to effectively control three species of insect potato disease vectors.