[Aim]  To explore the differences in secondary metabolites and volatile organic compounds among different resistant hosts of Matsucoccus matsumurae, and to identify eco-friendly insecticides and semiochemicals that influence insect behavior, with the aim of improving control strategies against M. matsumurae. This exotic invasive pest poses serious threats to pine forest health and ecological security. [Methods]  Non-volatile secondary metabolites (phenolic compounds) and volatile organic compounds were identified and analyzed in six pine species with varying resistance to M. matsumurae infestation, using targeted metabolomics and dynamic headspace GC/MS. [Results]  Tannins and phenolic acids, particularly catechins and epicatechins, in the bark of branches that are easily parasitized by M. matsumurae are positively correlated with resistance to this pest. A resistant species, Pinus sylvestris, has unique and relatively high levels of volatile organic compounds such as (+)-limonene, camphene, 3-carene, and γ-cadinene, whereas a susceptible species, P. densiflora, contains relatively higher levels of myrcene and phellandrene. [Conclusion]  Catechins and epicatechins can indicate whether a pine species is resistant to M. matsumurae. The specific volatile compounds found in different resistant tree species, such as (+)-limonene, camphene, 3-carene, γ-cadinene, myrcene, and phellandrene, may be attractive, or repellent, to M. matsumurae.