[Objectives]  Nosema ceranae mainly infects the digestive system of honeybees and is also thought to be a factor that may lead to Colony Collapse Disorder (CCD). The effects of N. ceranae on Apis mellifera have been intensively studied, however, there has been relatively little research on its effects on its original host, Apis cerana cerana. Workers of A. cerana cerana were infected by N. ceranae isolated from A. cerana cerana. We evaluated the impacts of N. ceranae on the health of A. cerana cerana by measuring the expression of immune genes and sugar concentration in the haemolymph. [Methods]  The expression of immune genes, including vitellogenin、abaecin、apidaecin、hymenoptaecin、defensin1、defensin2 and eater, was measured in infected and uninfected bees to determine whether infection with N. ceranae induced an immune response. We used HPLC analysis to quantitatively analyze the haemolymph of infected and uninfected A. cerana cerana, and measured concentrations of trehalose and glucose in the haemolymph under the same HPLC conditions. [Results]  Infected and uninfected bees of 14 and 7 days of age significantly differed in their expression of hymenoptaecin, vitellogenin, and defensin2, but the expression of other genes was not significantly different. The concentration of glucose and trehalose in the haemolymph of infected bees was not significantly different from that in uninfected bees. [Conclusion]  Expression of the immune genes hymenoptaecin, vitellogenin and defensin2 is induced in Apis cerana cerana of 7 and 14 days of age by infection with N. ceranae, but the concentration of glucose and trehalose in the haemolymph is not affected by infection.