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Your Position :Home->Past Journals Catalog->2019年56 No.2

Bioinformatic prediction of epitopes of the cuticular gene AACPR100A in Aedes agypti
Author of the article:CHEN Jing** LU Hao-Ran** ZHANG Lei LIAO Cheng-Hong*** HAN Qian***
Author's Workplace:(School of Bioscience and Pharmacy, Hainan University, Haikou 570228
Key Words:Aedes aegypti; epitope; DNAStar software; AaCPR100A
Abstract: 

[Objectives]  To predict the epitopes of the Aedes aegypti epidermis protein AaCPR100A. [Methods]  The secondary structure and hydrophobicity, surface probability and flexible regions of AaCPR100A were analyzed by DNAstar software to predict potential B cell antigen epitopes and potential T cell antigen epitopes. [Results]  The secondary structure of the AaCPR100A protein was rich in β-turns and random coils, and had high surface probability and flexibility. There were 7 potential B cell epitopes located at amino acid residues 18-29, 32-42, 47-82, 87-98, 111-178 and 194-248, or nearby, and also 11 potential T cell epitopes located at amino acid residues 20-24, 35-39, 44-48, 51-53, 79-82, 103-106, 109-112, 146-148, 150-152, 185-203 and 224-235, or nearby. [Conclusion]  The AaCPR100A protein contains both potential B cell antigen epitopes and potential T cell antigen epitopes. The predicted results provide a foundation for studies of the immunological properties and function of the AACPR100A protein, and suggest a potential target protein for mosquito control.

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