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Your Position :Home->Past Journals Catalog->2021年58 No.6

Progress in research on the relationship between aging, circadian rhythm and sleep in Drosophila
Author of the article:Lü Peng-Fei ZHAO Zhang-Wu DU Juan
Author's Workplace:MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China;MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China;MOA Key Laboratory of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China
Key Words:Drosophila; circadian rhythm; sleep; aging; clock genes
Abstract:
Both Drosophila and humans have a conservative circadian system. Research on the effects of aging on the circadian rhythm and sleep in Drosophila may aid understanding similar effects of aging in humans. The circadian clock is mainly comprised of an input system, core clock system and output system. Sleep is a kind of spontaneous, periodic and reversible resting state that is found in both simple and complex organisms. Circadian rhythm and sleep gradually weaken with age in Drosophila. Early in vivo and in vitro studies have found that the weakening of the circadian rhythm system with age in Drosophila is related to significant reduction in expression of the clock gene in peripheral neurons. However, the effects of aging on the expression of core circadian genes remains unclear. This paper reviews recent progress in research on the effects of aging on circadian rhythm and sleep in Drosophila.
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