With the rapid development of bioinformatics, insect genomics researches have been extended to the field of medicinal insects. At present, the genome of medicinal insects, for instance, Periplaneta american, Ericerus pela, Schlechtendalia chinensis, Mylabris cichorii, Epicauta chinensis, Mylabris aulica, Bombyx mori, Antheraea pernyi, Antheraea yamamai, have been sequenced, assembled and well analyzed. Here, we review the present research status of genomics researches on medicinal insects. From the perspective of multi-omics, the genome features of these medicinal insects were summarized, including the research progress of pharmacological active ingredients and the synthesis mechanism of medicinal insects. Besides, the prospects of applying the genomics researches on the development and production of insect medicinal materials are discussed.