Evolutionary plasticity of cytochrome P450 mediated insecticide resistance
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Key Words：Cytochrome P450, insecticide resistance, evolutionary plasticity
Abstract：Cytochrome P450 in insects is a supergene family. Increased detoxification of insecticides mediated by cytochrome P450s was proved to be an important and common mechanism of insecticide resistance. Recently, several studies have shown that insecticide resistance appears to evolve using different P450s or/and more than one P450 isoforms, and possibly different regulatory factors controlling P450 expression, even in insect strains selected with the same insecticide, indicating that the cytochrome P450 monooxygenases have some degree of plasticity in response to insecticide pressure: