[Objectives]  To measure the cross-resistance of a fenpropathrin-resistant strain of the mite Neoseiulus barkeri to commonly used pesticides in citrus orchards and thereby provide guidance for the use of such strains in biological pest control. [Methods]  The lethality and cross-resistance of a fenpropathrin-resistant strain of N. barkeri to commonly used pesticides in orange orchards were measured and the biological characteristics of this evaluated. [Results]  There were significant differences in the lethality of different insecticides to adult N. barkeri. High-efficiency cyfluthrin and chlorpyrifos were the most lethal with corrected mortality rates of 97.62% and 92.57%, respectively. The fenpropathrin-resistant strain of N. barkeri had significant cross-resistance to spirodiclofen, thiamethoxam, ethimazole, chlorpyrifos and high-efficiency cyfluthrin, being 7.56, 10.32, 11.45, 19.10 and 45.89 times, respectively, more resistant to these pesticides than a susceptible strain. The developmental period of the resistant strain was significantly longer than that of the sensitive strain, but there were no significant differences in the prey capture and hatching rates of these strains. Pyridaben, bufomite and fenpropathrin had significant effects on the hatching rate of both resistant and sensitive strains of N. barkeri, whereas most of other common pesticides had no effect on hatch rate. [Conclusion]  Fenpropathrin-resistance was associated with different levels of cross-resistance to common pesticides in orange orchards but had no significant effect on the growth, reproduction and prey capture rate of N. barkeri, which could be more widely used as a biological control.