[Aim]  To identify the best acaricide treatment, and reduce the amount of pesticides used, to control the apple spider-mite, Panonychus ulmi. [Methods]  The toxicity of abamectin, pyridaben, bifenazate and etoxazole, with, and without, the addition of the synergists green tangerine oil and agricultural organosilicon, was determined using the leaf dipping method. The effectiveness of each treatment in the field was assessed using the stem leaf spray method. [Results]  The LC₅₀ values (24 h) of abamectin, pyridaben, bifenazate and cyetpyrafen, were 2.711, 16.031, 4.534 and 1.768 mg/L, under laboratory conditions after 24 h. Blending 30% dilutions of the above pesticides with either green tangerine oil or agricultural organosilicon had obvious synergistic effects after 24 h. In the field, a dose of 1.35-2.70 g a.i./hm², abamectin was 67.35% to 82.31% effective one day after application. A dose of 2.70 g a.i./hm² cyetpyrafen achieved > 90% control after 3 and 7 d. 1, 3 and 7 d after administration, a mixture of 30% cyetpyrafen suspension 1.42 g a.i./hm² + GPOO and 30% cyetpyrafen suspension 1.42 g a.i./hm² + PEMSs, was the most effective treatment. [Conclusion]  Both abamectin and cyetpyrafen can prevent and control Panonychus ulmi, and can be used alternately to reduce the amount of pesticide applied. These results provide a scientific basis for the prevention and control of apple spider-mites in orchards in Xinjiang.