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Your Position :Home->Past Journals Catalog->2021年58 No.4

Progress in research on the use of RNAi delivery systems in pest control
Author of the article:XIAO Bei XING Shi-Si DENG Dan PENG Wei ZHAI Zong-Zhao
Author's Workplace:Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Hunan Normal University, Changsha 410081, China;Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Hunan Normal University, Changsha 410081, China
Key Words:RNA interference; ingestion; cuticular penetration; microbes; nanoparticles; pest control
Abstract:
RNAi is triggered by dsRNA and causes an efficient and specific cleavage of the target gene. Because of its high efficiency, specificity and convenience, RNAi is widely used in gene function studies, high throughput screening of target genes, gene therapy, drug target prediction and agricultural pest control. RNAi can offer unprecedented levels of control, but an appropriate approach, giving due consideration to potential barriers to RNAi efficiency, safety and the intended purpose of the knockdown, is fundamental to its successful deployment. We review and compare the efficiency of recent innovations in RNAi delivery, including the different delivery systems used in agricultural pest and vector pest control. We discuss future applications of RNAi delivery systems in pest control in order to promote advances in entomological research based on better RNAi technologies.
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