[Objectives]  To develop an efficient and environmental-friendly bait against termites. [Methods]  The toxicity of nitenpyram and chlorfenapyr baits to the termite Odontotermes formosanus was evaluated under laboratory conditions. Higher toxicity insecticides were chosen to determine their repellent effect on O. formosanus. Casing baits with three different pesticide doses were made in order to test both indoor toxicity and the effectiveness of control in the field. A suitable dose was chosen to carry out trials on the effectiveness of controlling O. formosanus in dams, which was subsequently tested by excavating termite nests. [Results]  The corrected mortality of O. formosanus reached 100% 72 h after treatment with 1.6 μg/mL nitenpyram and 16 μg/mL chlorfenapyr. The results of indoor toxicity test showed that the LC₅₀ of nitenpyram was lower than that of chlorfenapyr. Baits containing 100 μg/mL nitenpyram had no repellent effect on O. formosanus 8 h after treatment. The three different doses of nitenpyram casing baits all achieved a corrected mortality of 60% 72 h after treatment. Casing baits containing the three different doses were completely consumed by O. formosanus and there were no termites or signs of termite activity 45 days after baits had been deployed. Casing baits with 60 μg/g nitenpyram placed around dams in Fujian Province did not become moldy and were completely consumed by O. formosanus within three months. Moreover, there were no termites in tunnels and termite nests were either dead, or collapsed, six months after treatment. [Conclusion]  Casing baits containing 60 μg/g nitenpyram are an effective and environmentally-friendly method of controlling O. formosanus, both in the general landscape and in dams.